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生物材料与药物技术研究室
 

生物材料与药物技术研究室属于西北工业大学生命学院,是“空间生物实验模拟技术国防重点学科实验室”一个组成部分。目前,本研究室现有人员17名,其中教授2人、副教授3人、讲师1人,博士研究生4人、硕士生7人。 研究室主持承担的项目包括国家自然科学基金、国家973子课题、国家博士后基金、西北工业大学中央高校基础研究基金等多项科研项目。

一、 研究方向:

1、生物材料:

A. 生物制造与仿生;

B. 微纳生物载体材料;

C. 生物活性材料及表面涂层技术

2、药物技术:

A. 药物分子设计与活性筛选;

B. 靶向缓控释药物制剂;

C. 特种药物

二、 团队成员

三、 科研项目

1. 国家973课题(2012CB619101):金属植入材料功能化设计与生物适配机制研究,2012.1-2016.12;

2. 国家科技重大专项重大新药创制(2009ZX09103-113):MAP-5-FU结肠癌双靶向候选药物研究2009.9-2012.8;

3. 国家自然科学基金面上项目(20872119):亲脂性二膦酸盐的合成及其对失重引起骨丢失的活性研究,2009.1-2011.12;

4. 国家自然科学基金青年项目(21202130):用于标记糖的荧光探针的设计合成及其示踪寡糖吸收机制研究,2013.1-2015.12;

5. 国家自然科学基金青年基金项目(51103116):聚合物胶束与药物间相容性与增溶作用的相关性及分子机制研究,2012.1-2014.12;

6. 中央高校基础科研基金自由探索面上项目:微量元素原位掺杂介孔二氧化硅及其对骨再生的调控机制,2016.01-2017.12;

7. 中央高校基本科研业务费科研资助项目(3102015ZY085):趋化因子修饰支架材料原位招募自体干细胞及巨噬细胞响应,2015.1-2016.12;

8. 中央高校基本科研业务费专项资金资助(3102014JKY15005):利鲁唑衍生物的合成及其镇痛作用机制研究,2014.5-2016.5;

9. 中央高校基础科研基金(WO18104):亲脂性二膦酸盐对抗空间骨丢失的设计与合成,2008.1-2010.12;

10. 陕西省自然科学基金面上项目(2015JM2067):利鲁唑衍生物的合成及其镇痛作用机制研究,2015.1-2016.12;

11. 陕西省自然科学基础研究计划面上项目(2015JM5177):负载生长因子的PLGA基纳米纤维材料的研究,2015.1-2016.12;

12. 陕西省自然科学基金项目(2010JM2021):正电荷磷脂高分子的设计、合成与性能研究,2010,6-2012,12。

四、 研究成果

pH敏感水凝胶

离子交换型结肠靶向树脂微囊

还原响应性纳米胶束

五、 发表论文

1. Chen, Qiang, Li, Wei, Yao, Qingqing, Liang, Ruifang, Pérez-Garcia Rosalina, Munoz, Josemari, Boccaccini Aldo R.. Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition.Journal of Materials Chemistry B. 4(29): 5035-5045. 2016.

2. Song Jiankang, Chen Qiang, Zhang Yang, Mani Diba, Eva Kolwijck, Shao Jinlong, John A. Jansen, Fang Yang, Aldo R. Boccaccini, Sander C. G. Leeuwenburgh. Electrophoretic deposition of chitosan coatings modified with gelatin nanospheres to tune the release of antibiotics.ACS applied materials & interfaces, DOI: 10.1021/acsami.6b03454. 2016.

3. Wen Zhao, Jiaojiao Li, Kaixiang Jin, Wenlong Liu, Xuefeng Qiu, Chenrui Li, Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering.Materials Science & Engineering C, 2016, 59:1181-1194.

4. Qi Hongfei, Ye Zhihong, Ren Hailong, Chen Nana, Zeng Qingyan, Wu Xianglong,Lu Tingli. Bioactivity assessment of PLLA/PCL/HAP electrospun nanofibrous scaffolds for bone tissue engineering.Life sciences. 148: 139-144. 2016.

5. Dong K, Yan Y, Wang PC, Shi XP, Zhang L, Wang K, Xing JF, Dong YL. Biodegradable mixed MPEG-SS-2SA/TPGS micelles for triggered intracellular release of paclitaxel and reversing multidrug resistance.International Journal of Nanomedicine. 2016, 11: 5109-5123.

6. Dong K, Zhang HF, Yan Y, Sun JY, Dong YL, Wang K, Zhang L, Shi XP, Xing JF.Improvement of side-effects and treatment on the experimental colitis in mice of a resin microcapsule loading hydrocortisone sodium succinate.Drug Development and Industrial Pharmacy. 2016, DOI:10.1080/03639045.2016.1258410.

7. Dong K, Zeng AG, Wang ML, Dong YL, Wang K, Guo CN, Yan Y, Zhang L, Shi XP, Xing JF. In vitro and in vivo study of a colon-targeted resin microcapsule loading a novel prodrug, 3, 4, 5-tributyryl shikimic acid.RSC Advances. 2016, 6: 16882-16890.

8. Qiang Chen, Wei Li, Ourania-Menti Goudouri, Yaping Ding, Sandra Cabanas-Polo, and Aldo R. Boccaccini. Electrophoretic deposition of antibiotic loaded PHBV microsphere-alginate composite coating with controlled delivery potential.Colloids and Surfaces B: Biointerfaces130 (2015) 199-206.

9. Qiang Chen, Sandra Cabanas-Polo, Yaping Ding, Aldo. R. Boccaccini, Bioactive glass-biopolymer multilayer coatings fabricated by electrophoretic deposition combined with layer-by-layer assembly,Key Engineering Materials654 (2015): 170-175.

10. Dong K, Dong YL, You CY, Xu W, Huang XY, Zhang L, Wang K, Xing JF. Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel.Drug Delivery. 2016, 23(1): 174-184.Wen Zhao, Wenlong Liu, Jiaojiao Li, Xiao Lin, Ying Wang. Preparation of animal polysaccharides nanofibers by electrospinning and their potential biomedical applications.Journal of Biomedical Materials Research: Part A, 2015, 103: 807-818.

11. Qiang Chen, Liu Yufang, Yao Qingqing, Yu Shanshan, Zheng Kai, Pischetsrieder, Monika, A. R. Boccaccini. Multilayered bioactive composite coatings with drug delivery capability by electrophoretic deposition combined with layer-by-layer deposition.Advanced Biomaterials and Devices in Medicine1 (2014) 18-27.

12. Qiang Chen, Uxua Pérez de Larraya, Nere Garmendia, María Lasheras-Zubiate, Luis Cordero-Arias, Sannakaisa Virtanen, Aldo R. Boccaccini. Electrophoretic deposition of cellulose nanocrystals (CNs) and CNs/alginate nanocomposite coatings and free standing membranes.Colloids and Surfaces B: Biointerfaces,118 (2014): 41-48.

13. Qiang Chen, Sandra Cabanas-Polo, Ourania-Menti Goudouri, Aldo R. Boccaccini. Electrophoretic co-deposition of polyvinyl alcohol (PVA) reinforced alginate–Bioglass® composite coating on stainless steel: Mechanical properties and in-vitro bioactivity assessment.Materials Science and Engineering: C, 40 (2014): 55-64.

14. Tingli Lu, Ting Chen, Yuankun Zhai, Yufan Ma, Yuehong Xiao. Designer Functionalized Self-Assembling Peptide Scaffolds for Adhesion, Proliferation, and Differentiation of MC3T3-E1.Soft Materials. 12, 79-87, 2014.

15. X. L. Wu, W.T. Fan, Y. L. Pan, et al. Synthesis, crystal structure and anti-fatigue effects of some benzamide derivatives.Molecules. 2014, 19: 1034-1046.

16. X. L. Wu, W.T. Fan, Y. L. Pan, et al. Synthesis, spectroscopic properties, and biological applications of eight novel chlorinated fluorescent proteins-labeling probes.Journal of Fluorescence. 2014, 24(3):775-786.

17. Dong K, Dong YL, You CY, Xu W, Huang XY, Yan Y, Zhang L, Wang K, Xing JF. Assessment of the safety, targeting, and distribution characteristics of a novel pH-sensitive hydrogel.Colloid and Surface B-Biointerfaces. 2014, 123: 965-973.

18. Tingli Lu, Yuhui Li, Tao Chen. Techniques of Fabrication and Construction Three-dimensional Scaffolds for Tissue Engineering.International Journal of Nanomedicine. 8: 337–350, 2013.

19. Tingli Lu,Yuhui Li, Yunqing Wang, et al. Preparation and characterization of porous nano-sized hydroxyapatite/collagen composite as bone scaffold.Advanced Materials Research. 647: 62-66, 2013.

20. Wen Zhao, Hong Zhang, TingLi Lu, Wenlong Liu. Electrostatic self-assembly: an innovative approach to fabricate novel-structured magnetic liposomes.Applied Surface Science, 2013, 265: 101-107.

21. Wen Zhao, Wenlong Liu. Compatibility between Paclitaxel and Polymer Carrier.Applied Mechanics and Materials. 2013,420: 263-268.

22. Dong K, Xu W, You CY, Xing JF, Zhang JY, Gao Y, Wang K. Novel Biodegradable pH/Thermosensitive Hydrogels: Part 1. Preparation and Characterization.International Journal of Polymeric Materials and Polymeric Biomaterials.2013, 62(14): 726-732.

23. Qiang Chen, Luis Cordero-Arias, Judith A. Roether, Sandra Cabanas-Polo, Sannakaisa Virtanen, Aldo R. Boccaccini. Alginate/Bioglass® composite coatings on stainless steel deposited by direct current and alternating current electrophoretic deposition.Surface and Coatings Technology,233 (2013): 49-56.

24. Tingli Lu, Zhao Wang, Yufan Ma, Yang Zhang, Tao Chen. Influence of polymer size, liposome composition, surface charge and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid).International Journal of Nanomedicine. 7: 4917–4926.2012

25. Tingli Lu, Weiguang Sun, Wen Zhao, Tao Chen. Preparation of amifostine polylactide–co-glycolide microspheres and its irradiation protection in mouse through oral administration.Drug Development and Industrial Pharmacy. 37(12): 1473-1480, 2011.

26. Tingli Lu, Yufan Ma, Huijing Hu, Yun Chen, Wen Zhao, Tao Chen. Ethinylestradiol liposome preparation and its effects on ovariectomized rats’ osteoporosis,Drug Delivery. 18(7): 468-477, 2011.

27. Tingli Lu, Huijing Hu, Wen Zhao, Tao Chen. Synthesis and in vivo bioactivity of lipophilic alendronate derivatives against osteoporosis.Drug Development and Industrial Pharmacy. 37(6): 656-663, 2011.

28. X. L. Wu, X. L. Jin, Y. X. Wang, J. L. Li, Z. Shi, Synthesis and spectral properties of novel chlorinated pH fluorescent probes.J. Lumin. 2011, 131(4): 776-780.

六、 发明专利

1. 二膦酸盐衍生物的制备方法. ZL 2006 1 0105179.2

2. 淫羊霍提取物脂肪乳组合物及其制备方法. ZL 2006 1 0105343.X.

3. 雌激素脂质体的制备方法. ZL 2007 1 0017233.2

4. 磁性脂质体及其制备方法. ZL200910022717

5. 甲氟喹脂肪乳组合物及其制备方法. ZL 200910020907

6. 蒿甲醚/本芴醇复方脂肪乳静脉注射剂及其制备方法. ZL201010216610.7

7. 单甲氧基聚乙二醇-聚L-色氨酸两亲性嵌段共聚物及其制备方法以及其载药胶束溶液的制备方法. ZL 201110132965.2

8. 苯甲酰胺化合物及其制备方法. ZL201110148165.X

9. 一种富含***冻干粉及制备方法.国防发明专利. ZL 201318006417.5

10. 具有***药理活性化合物的制备及其使用方法.国防发明专利. ZL201318006415.6

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