主  题：Intelligent, Nanoscale Systems for Advanced Targeting and Delivery of Therapeutic Agents: The Future of Disease Treatment

报告人：Nicholas A. Peppas

时  间：2019年5月27日（星期一）09:30

地  点：友谊校区国际会议中心第一会议室

主  办：党委学生工作部

承  办：生命学院

1.报告内容简介

Engineering the molecular design of intelligent biomaterials by controlling structure, recognition and specificity is the first step in coordinating and duplicating complex biological and physiological processes. Recent developments in siRNA and protein delivery have been directed towards the preparation of targeted formulations for protein delivery to specific sites, use of environmentally-responsive polymers to achieve pH- or temperature-triggered delivery, usually in modulated mode, and improvement of the behavior of their mucoadhesive behavior and cell recognition. We address design and synthesis characteristics of novel crosslinked networks capable of protein release as well as artificial molecular structures capable of specific molecular recognition of biological molecules. Molecular imprinting and micro-imprinting techniques, which create stereo-specific three-dimensional binding cavities based on a biological compound of interest, can lead to preparation of biomimetic materials for intelligent drug delivery, drug targeting, and tissue engineering. We have been successful in synthesizing novel glucose- and protein-binding molecules based on non-covalent directed interactions formed via molecular imprinting techniques within aqueous media. We have also developed structurally superior materials to serve as effective carriers for siRNA delivery to combat Crohn disease and ulcerative colitis.

2.Nicholas A. Peppas教授简介

Nicholas A. Peppas，科学博士，美国工程院、医学院、科学艺术研究院三院院士，中国工程院外籍院士，法国国家科学院院士，西班牙国家皇家学会成员。他于1973年在麻省理工学院获得科学博士学位，现任德克萨斯大学奥斯汀分校生物材料、药物输送和再生医学研究所所长，科克雷尔家族董事会化学、生物医学工程、儿科、外科和药剂科系主席教授。与此同时，他还担任四川大学，北京协和医学院，解放军医学院以及北京航空航天大学的荣誉教授。Peppas教授是生物材料，药物递送系统和生物纳米技术领域的全球领军人物。他通过多学科交叉的方法，建立了生物医学系统的基本原理和理性设计方法，并开发了控释装置和生物组织中药物和蛋白质扩散的模型。目前，他共计发表学术论文1100余篇，专著及编著37部，获授权专利48项，论文他引32000多次。2012年他获得了美国国家工程院（NAE）创始人奖，为工程院对该领域的最高等级奖项。2018年，他获得了美国国家医学院的Adam Yarmolinsky奖。此外，他还担任《Regenerative Biomaterials》杂志编辑，也是《Science Advances》杂志副主编。

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