讲座题目：代谢与生殖紊乱发生机制的探究

Using the Combined Power of Classical and Chemical Genetics in C. elegans to Understand Human Metabolic Disorders

报告人：吴连锋研究员

时间：2020年12月11日（星期五）16:00-17:30

地点：线上

腾讯会议ID：810 549 576

https://meeting.tencent.com/s/XmgKRaRADdSj

邀请人：牛卫宁教授

承办单位：生命学院

主讲人简介

吴连锋，博士，西湖大学生命科学学院研究员；2010年博士毕业于中国科学院生物物理研究所；2011年-2017年，在哈佛医学院麻省总医院做博士后研究，从事代谢与衰老相关疾病发生发展分子机制的研究，期间的工作揭示了抗糖尿病药物二甲双胍作用的分子遗传机制，该工作在生物医学领域顶尖期刊Cell上以“Featured Article”形式发表并附有同行专家评论；2017年9月，加入西湖大学开展独立研究，实验室致力于探讨代谢与衰老相关疾病发生发展的分子机理和开发代谢相关疾病的新型干预措施等的研究，主要研究内容包括但不限于：1）抗2型糖尿病药物二甲双胍的作用机制及二甲双胍类似药物的筛选；2）线粒体、溶酶体等细胞器在代谢及代谢相关疾病中的作用；3）能量代谢的分子遗传机制。

讲座内容简介

 Metforministhe first-line therapy for type 2 diabetes (T2D) worldwide and has ability to treat patients with Polycystic Ovary Syndrome (PCOS). Molecular or genetic mechanisms responsible for occurrence of these metabolic diseases are largely unknown. Although metformin has been long used in clinic, its mode of action also remains elusive. The ultimate goal of our research is to unveil the machineryorthe most fundamental biology underlying occurrence of these metabolic diseases through better understanding on how metformin works.

During the talk, our recent progress on achieving the central aimswill bepresentedand discussed. Conclusively, 1) out of forward genetic screen, we identified five genes working in the same pathway to generate lysosome related organelles, which can mimic effect of metformin when mutated inC. elegansand mice; 2) a feasible genetic model for PCOS study in nematode animals is proposed, within which metformin and its mimicker tryptophan can rescue worms’ PCOS-like phenotypes; 3) chemical genetics is applied to develop better options than metformin for T2D and PCOS treatment, the rational and approaches for which will be delivered.