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科研团队
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化学生物学与分子工程研究室
  审核人:

本研究室现有副教授3名,其中包括博士生导师1名,硕士生导师3名,在读博士、硕士研究生共17人。主持国家自然科学基金6项、陕西省重点研发计划等省部级课题7项以及其它各类课题20余项。授权国家发明专利6项,发表论文30余篇。获得陕西省科学技术三等奖和西安市科学技术二等奖各1项。

研究方向一

●氧化还原应激调控硫/H2S代谢的机制及其对细胞能量代谢的影响

●氧化还原应激与肿瘤发生机制的研究及其药物筛选

研究方向二

生物活性多肽的功能研究。

● 神经肽介导的微生物-脑-肠轴对肠道屏障功能的调控机制

● 动物源性防御肽-必需微量元素-益生菌类复合微生态制剂的研制

● 线粒体靶向肽影响细胞能量代谢的机制

研究方向三

糖生物学研究。

● 多糖分子结构和功能、构效关系及生物活性机制研究

● 活性寡糖维护机体健康的机理研究

研究方向四

●生物催化合成药物中间体

●医疗诊断用酶的产业化制备

科研项目

主持国家自然科学基金面上项目3项(项目编号:31871145;31672435;31471086);

主持国家自然科学基金青年项目3项;

主持陕西省重点研发计划项目2项;

主持陕西省科技攻关项目3项;

主持企业横向课题、中央高校基本科研业务费等其它项目10余项。

近期代表性论文

[1]Niu WN*, Wang J, Qian J, Wang MY, Wu P, Chen F, Yan SS. Allosteric control of human cystathionineβ-synthase activity by a redox active disulfide bond.J. Biol. Chem.2018, 293(7):2523-2533

[2]Niu WN*, Chen F, Wang J, Qian J, Yan SS. Antitumor effect of sikokianin C, a selective cystathionineβ-synthase inhibitor, against human colon cancerin vitroandin vivo.Med Chem Commun. 2018, 9:113-120

[3]Niu WN*, Cao SS, Yang ML, Xu L. Enzymatic Synthesis of S-Adenosylmethionine Using Immobilized Methionine Adenosyltransferase Variants on the 50-mM Scale.Catalysts2017, 7(8), 238.

[4]Niu WN*, Wu P, Chen F, Wang J, Shang XY, Xu CL. Discovery of selective cystathionineβ-synthase inhibitors by high-throughput screening with a fluorescent thiol probe.Med Chem Commun. 2017, 8:198-201

[5]Niu WN,Yadav PK, Adamec J, Banerjee R*. S-Glutathionylation Enhances Human Cystathionine-β- synthase Activity Under Oxidative Stress Conditions.Antioxid Redox Signal. 2015, 22(5): 350-361 (封面论文)

[6]Chunlan Xu* , Yu Guo,Lei Qiao,Li Ma,Yi-yi Cheng. Preparation, characteristics and antioxidant activity of polysaccharides and proteins-capped selenium nanoparticles synthesized byLactobaccillus caseiATCC 393.Carbohydrate Polymers. 2018, 195: 576-585.

[7]Chunlan Xu* , Yu Guo,Lei Qiao,Li Ma,Yiyi Cheng, Alexandra Roman. Biogenic synthesis of novel functionalized selenium nanoparticles byLactobacillus casei393 and its protective effects on intestinal barrier dysfunction caused by EnterotoxigenicEscherichia coliK88.Frontiers in Microbiology. 2018, 9: 1129.

[8]Chunlan Xu* , Yu Guo,Lei Qiao,Li Ma,Yiyi Cheng. Recombinant vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats.World Journal of Gastroenterology. 2018,24(6):706-715.

[9]Chunlan Xu*,Yu Guo,Xiangjin Qiao,Xiaoya Shang,Weining Niu,Mingliang Jin*,Design, recombinant fusion expression and biological evaluation of vasoactive intestinal peptide analogue as novel antimicrobial agent. Molecules. 2017, 22:1963.

[10]Chunlan Xu,Sally Ghali,Jiani Wang,et al. CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway. Scientific Reports. 2017, 7:16351

[11]Chunlan Xu*,XJ Qiao, Y.F.Zhao, R.Sun, X.Y.Shang, W.N.Niu.Resveratrol ameliorates chronic high altitude exposure-induced oxidative stress and lipid metabolism alteration in rats.European Journal of Lipid Science and Technology. 2016, 118:612-621.

[12]Chunlan Xu*,Youming Wang; Rui Sun,Xiangjin Qiao,Xiaoya Shang,Weining Niu,Modulatory Effects of Vasoactive Intestinal Peptide on Intestinal Mucosal Immunity and Microbial Community of Weaned Piglets Challenged by an EnterotoxigenicEscherichia coli(K88).PLos One. 2014, 9(8):e104183.

[13]Chunlan Xu*, R.Sun, XJ Qiao, C.C.Xu, X.Y.Shang, W.N.Niu,Protective effect of glutamine on intestinal injury and bacterial community in rats exposed to hypobaric hypoxia environment.World Journal of Gastroenterology. 2014, 20(16): 4467-4838.

[14]Chunlan Xu*, R.Sun, XJ Qiao, C.C.Xu, X.Y.Shang, W.N.Niu, Y. Chao,Effect of vitamin E supplementation on intestinal barrier function in rats exposed to high altitude hypoxia environment.Korean Journal of Physiology & Pharmacology. 2014,18:1-8.

[15]Chunlan Xu*, C.Dong, C.C.Xu, T.T. Han, S.Bao, X.B.Gao. Effect of iron glycinate chelate on the expression of hypoxia-inducible factor and antioxidant status in rats exposed to high altitude hypoxia environment.Biological Trace Element Research. 2014, 162:142-152.

[16]Shang XY*, Chao Y, Zhang Y, Lu CY, Xu CL, Niu WN. Immunomodulatory and antioxidant effects of polysaccharides from Gynostemma pentaphyllum Makino in immunosuppressed Mice.Molecules, 2016, 21 (8): 1085.

[17]Jiani Wang, Sally Ghali,Chunlan Xu, et al. Ceragenin CSA13 reduces Clostridium difficile infection in mice by modulating the intestinal microbiome and metabolites.Gastroenterology. 2018, 154(6): 1737-1750.

[18]Hon Wai Koon, Bowei Su,Chunlan Xu, et al. ProbioticSaccharomyces boulardiiCNCM I-745 prevents outbreak-associatedClostridium difficile-associated cecal inflammation in hamsters.American Journal of Physiology- Gastrointestinal and Liver Physiology. 2016, 311(4):G610-G623.

[19] Gherasim C, Yadav PK, Kabil O,Niu W-N, Banerjee R, Nitrite Reductase Activity and Inhibition of H2S Biogenesis by Human Cystathionine ß-Synthase.PLoS ONE, 2014, 9(1): e85544

联系方式

牛卫宁,博导,E-mail:niuweining@nwpu.edu.cn

尚晓娅,硕导,E-mail:loyamuyu@nwpu.edu.cn

徐春兰,硕导,E-mail:clxu@nwpu.edu.cn

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